MicroRNA-486-5p and microRNA-486-3p: Multifaceted pleiotropic mediators in oncological and non-oncological conditions
نویسندگان
چکیده
منابع مشابه
The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis
To identify microRNAs (miRNAs, miRs) with potential roles in lung fibrogenesis, we performed genome-wide profiling of miRNA expression in lung tissues from a silica-induced mouse model of pulmonary fibrosis using microarrays. Seventeen miRNAs were selected for validation via qRT-PCR based on the fold changes between the silica and the control group. The dysregulation of five miRNAs, including m...
متن کاملMicroRNA 486-3P as a stability marker in acute coronary syndrome
Easily accessible biomarkers are needed to diagnose cardiovascular disease precisely-particularly, to distinguish between disease subtypes that are encountered in clinical practice. Per the hypothesis that plasma miRNA is valuable for this purpose, we performed complete transcriptional profiling of an miRNA discovery-set in 14 samples: three patients with ST-elevated acute myocardial infarction...
متن کاملMicroRNA-486-3p Regulates γ-Globin Expression in Human Erythroid Cells by Directly Modulating BCL11A
MicroRNAs (miRNAs) play key roles in modulating a variety of cellular processes through repression of mRNAs target. The functional relevance of microRNAs has been proven in normal and malignant hematopoiesis. While analyzing miRNAs expression profile in unilineage serum-free liquid suspension unilineage cultures of peripheral blood CD34(+) hematopoietic progenitor cells (HPCs) through the eryth...
متن کاملMicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.
Children with Down syndrome (DS) are at increased risk for acute myeloid leukemias (ML-DS) characterized by mixed megakaryocytic and erythroid phenotype and by acquired mutations in the GATA1 gene resulting in a short GATA1s isoform. The chromosome 21 microRNA (miR)-125b cluster has been previously shown to cooperate with GATA1s in transformation of fetal hematopoietic progenitors. In this stud...
متن کاملMicroRNA-486 down-regulates p53 expression in the diabetic retinopathy
Objective: To investigate the role of miR-486 in the pathogenesis of diabetic retinopathy and the possible mechanism involved in it. Methods: Electroretinography was used to measure the function of STZ (streptozotocin)induced diabetic mice. MiRNA expression changes in the retinas of STZ-induced diabetic mice were identified by miRNA-specific microarray and further confirmed by quantitative RT-P...
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ژورنال
عنوان ژورنال: Non-coding RNA Research
سال: 2020
ISSN: 2468-0540
DOI: 10.1016/j.ncrna.2020.01.001